Philip Osdoby

Philip Osdoby

Professor of Biology
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    • Washington University
      CB 1137
      One Brookings Drive
      St. Louis, MO 63130-4899
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    Philip Osdoby's research focuses on understanding select aspects of the cell and molecular interactions that are required for normal bone development as well as those that may contribute to age-associated and inflammatory-mediated pathological bone loss.

    The bone cell microenvironment consists of bone-forming osteoblasts, bone-resorbing osteoclasts, and thei precursors, as well as immune and vascular cells. Complex endocrine and local signals are integrated to mediate bone cell development and function.

    recent courses

    Endocrine Physiology

    Biochemical, physiological, and regulatory properties of the mammalian endocrine system at the molecular, cellular, and systemic level with a focus on human physiology and development. Topics will explore endocrine cell signaling, molecular mechanisms of hormone action, homeostasis and feedback systems including neuroendocrine integration of physiological processes, endocrine control of cardiovascular and calcium homeostasis, and select discussion of endocrine pathologies. In addition to class and textbook material there will be exposure to the primary research literature.

      Regenerative Medicine: Cell Based Therapies and Tissue Engineering

      Regenerative medicine focuses on the development of novel therapies to repair, replace, restore or regenerate cells, tissues and body organs that are defective, damaged or injured by disease. Cell-based therapies, including the use of native stem or immune cells and genetically-modified or bioengineered cells, are being evaluated for the treatment of a wide variety of diseases such as cancer, diabetes, and Parkinson's disease. This course will highlight basic, translational, and clinical advances in cell-based therapies and tissue engineering, with some discussion of ethical, financial, and regulatory issues that may impact such advances.

        Selected Publications

        Collin-Osdoby P, Osdoby P. 2012. RANKL-mediated osteoclast formation from murine RAW 264.7 cells. Methods Mol Biol. 2012;816:187-202.  PMID: 22130930.

         

         

        Kovacs CS, Chaussain C, Osdoby P, Brandi ML, Clarke B, Thakker RV. 2021. The role of biomineralization in disorders of skeletal development and tooth formation. Nat Rev Endocrinol. 2021 Jun;17(6):336-349. PMID: 33948016.

         

        Sunyer, T., Lewis, J., Collin-Osdoby, P., Osdoby, P. (1999) Estrogen inhibits interleukin-1 response of human marrow-derived osteoclast-like cells by modulating isoforms of IL-1 receptor expression. J. Clin. Invest. 103: 1409-1418.

        Collin-Osdoby, P., Rothe, L., Becker, S., Anderson, F., Osdoby, P. (2000) Decreased nitric oxide levels promote osteoclast formation and bone resorption in chick bone marrow and isolated osteoclast cultures in vitro as well as in vivo on the chick chorioallantoic membrane in conjunction with neoangiogenesis. J. Bone Min. Res. 15: 474-488.

        Wright, L., Beck, S., Schwent, B., Anderson, F., Moura, P., Nelson, M., Maloney, W., Collin-Osdoby, P., Osdoby, P. (2000) The chemokine receptor CXCR4 and its ligand, SDF-1, are involved in human osteoclast SDF-1, are involved in human osteoclast. Submitted to J. Clin. Invest.

        Collin-Osdoby, P., Rothe, L., Anderson, F., Nelson, M., Maloney, W., Osdoby, P. (2001) Receptor activator of NF-kappa B and osteoprotegerin expression by human microvascular endothelial cells, regulation by inflammatory cytokines, and role in human osteoclastogenesis. J. Biol. Chem. 276(23): 20659-20672.

        Gorski, J., Liu, F., Artigues, A., Castagna, L., and Osdoby, P. (2002) New alternatively spliced form of galectin-3, a new member of the beta-galactosidase-binding animal lectin family, contains a predicted transmembrane-spanning domain and a leucine zipper motif. J Biol. Chem. 277: 18840-18848.

        Collin-Osdoby, P., Rothe, L., Bekker, S., Anderson, F., Huang, Y., and Osdoby, P. (2002) Basic fibroblast growth factor stimulates osteoclast recruitment, development, and bone pit resorption in association with angiogenesis in vivo on the chick chorioallantoic membrane and activates isolated avian osteoclast resorption in vitro. J. Bone Miner. Res. 17:1859-1871.

        Yu X, Huang Y, Collin-Osdoby P, Osdoby P, (2003) Stromal cell-derived factor-1(SDF-1) recruit osteoclast precursors by inducing chemotaxis, matrix metalloproteinase-9 (MMP-9) activity, and collagen transmigration. Journal of Bone and Mineral Research. 18 1404-1418.

        Collin-Osdoby P, Yu X, Zheng H, Osdoby P. (2003) RANKL-mediated osteoclast formation from murine RAW 264.7 cells. In: Methods in Molecular Medicine. Bone Research Protocols. S Ralston, M Helfrich, eds. Human Press, Totowa, NJ. pgs 153-166.

        Yu X, Huang Y, Collin-Osdoby P, Osdoby P. (2004) CCR1 chemokines promote the chemotactic recruitment, RANKL development, and motility of osteoclasts and are induced by inflammatory cytokines in osteoblasts. Bone Miner Res 19:2065-2077.

        Wright L, Maloney W, Yu X, Kindle L, Collin-Osdoby P, Osdoby P. (2005) Stromal cell-derived factor-1 binding to its chemokine receptor CXCR4 on precursor cells promotes the chemotactic recruitment, development and survival of human osteoclasts. Bone.2005;36(5):840-53. 2005

        Saltman L, Javed A, Ribadeneyra J, Hussain S, Young D, Osdoby P, Amcheslavsky A, van Wijnen A, Stein J, Stein G, Lian J, Bar-Shavit Z (2005) Organization of transcriptional machinery and regulatory factors in osteoclasts nuclei: Compartmentalization of Runx1. J Cell Physiol. 2005:871-80

        Kindle L, Rothe L, Kriss M, Osdoby P, Collin-Osdoby P. (2006) Human microvascular endothelial cell activation by IL-1 and TNF-a stimulates the adhesion and transendothelial migration of circulating human CD14+ monocytes that develop with RANKL into functional osteoclasts. J Bone Miner Res 21: 193-206.

        Zheng, H. Yu, H., Collin-Osdoby, P. Osdoby, P. (2006) RANKL Stimulates iNOS and NO production in Developing Osteoclasts via NF-kB: An Autocrine Negative Feedback Mechanism to Regulate Osteoclastogenesis and Bone Resorption. J Biol Chem.;281(23):15809-20.